High glucose induces dysfunction and apoptosis in endothelial cells: is the effect of high glucose persistence more important than concentration?

@article{Zhang2011HighGI,
  title={High glucose induces dysfunction and apoptosis in endothelial cells: is the effect of high glucose persistence more important than concentration?},
  author={Yang Zhang and Hong Shi and G-y Sun and Su-min Li and X Xu and Changlan Ye and Xi-tao Li and S Wang},
  journal={Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association},
  year={2011},
  volume={119 4},
  pages={225-33}
}
Oxidative stress and inflammation are involved in the pathogenesis of diabetic endothelial dysfunction. Herein we reported the biological changes induced by hyperglycemia in human umbilical vein endothelial cells (HUVECs) and the potential underlying mechanisms sought to determine whether high glucose concentration or the persistence plays a key role in the… CONTINUE READING