High glucose induces cardiac insulin-like growth factor I resistance in ventricular myocytes: role of Akt and ERK activation.

@article{Ren2003HighGI,
  title={High glucose induces cardiac insulin-like growth factor I resistance in ventricular myocytes: role of Akt and ERK activation.},
  author={Jun Ren and Jinhong Duan and Kadon K. Hintz and Bonnie H. Ren},
  journal={Cardiovascular research},
  year={2003},
  volume={57 3},
  pages={
          738-48
        }
}
OBJECTIVE Cardiac resistance to IGF-1 occurs in diabetes and is attributed to cardiac dysfunction in diabetes. However, the mechanism of action responsible for cardiac IGF-1 resistance is still unknown. This study was designed to examine the impact of high glucose on IGF-1-induced contractile response and activation of serine-threonine kinase Akt as well as extracellular signal-regulated kinase (ERK1/2) in cardiac myocytes. METHODS Isolated adult rat ventricular myocytes were cultured for 12… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 27 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 30 REFERENCES

Insulin - like growth 2 1 mechanisms mediate the stretch dependence of Ca release in factorI rapidly activates multiple signal transduction pathways in cardiomyocytes

  • MG Petroff, SH Kim, S Pepe, R Foncea, M Andersson, A Ketterman
  • Nat Cell Biol
  • 2003

Influence of age on inhibits the development of diabetic cardiomyopathy and angiotencontractile response to insulin - like growth factor I on ventricular sin IImediated oxidative stress

  • J Kajstura, F Fiordaliso, +4 authors RA Brown
  • Am J Physiol Endocrinol Metab
  • 2002

Insulin - like growth factor 1 and the heart

  • PH Wang
  • 2002

IGF-1 attenuates

  • FL Norby, LE Wold, J Duan, KK Hintz, J. Ren
  • Am J Physiol Endocrinol Metab ;283:E658–E666…
  • 2001
2 Excerpts

IGF-1 overexpression

  • J Kajstura, F Fiordaliso, AM Andreoli
  • Diabetes
  • 2001
2 Excerpts

Reperfusion-activated 1992;130:145–151

  • K Yamashita, J Kajstura, DJ Discher
  • Circ Res
  • 2001
3 Excerpts

Akt promotes signaling pathway promotes compensated cardiac hypertrophy in survival of cardiomyocytes in vitro and protects against ischemia– transgenic mice

  • OF Bueno, LJ De Windt, KM Tymitz
  • EMBO J ;19:6341–6350
  • 2000
1 Excerpt

Similar Papers

Loading similar papers…