High glucose induces apoptosis and suppresses proliferation of adult rat neural stem cells following in vitro ischemia

@inproceedings{Chen2012HighGI,
  title={High glucose induces apoptosis and suppresses proliferation of adult rat neural stem cells following in vitro ischemia},
  author={Jian Chen and Yang Guo and Wei Cheng and Ruiqing Chen and Tianzhu Liu and Zhenzhou Chen and Sheng Neng Tan},
  booktitle={BMC Neuroscience},
  year={2012}
}
Post-stroke hyperglycemia appears to be associated with poor outcome from stroke, greater mortality, and reduced functional recovery. Focal cerebral ischemia data support that neural stem cells (NSCs) play an important role in post-ischemic repair. Here we sought to evaluate the negative effects of hyperglycemia on the cellular biology of NSCs following anoxia, and to test whether high glucose affects NSC recovery from ischemic injury. In this study, we used immortalized adult neural stem cells… CONTINUE READING
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