High glucose induces MCP-1 expression partly via tyrosine kinase-AP-1 pathway in peritoneal mesothelial cells.

@article{Lee2001HighGI,
  title={High glucose induces MCP-1 expression partly via tyrosine kinase-AP-1 pathway in peritoneal mesothelial cells.},
  author={Sang-Ho Lee and Beom Seok Kim and Won Seok Yang and Soon Bae Kim and Su Kil Park and Jung Sik Park},
  journal={Kidney international},
  year={2001},
  volume={60 1},
  pages={
          55-64
        }
}
BACKGROUND High glucose in peritoneal dialysis solutions has been implicated in the pathogenesis of peritoneal fibrosis in chronic ambulatory peritoneal dialysis (CAPD) patients. However, the mechanisms are not very clear. Peritoneal macrophages seem to participate in the process of peritoneal fibrosis and monocyte chemoattractant protein-1 (MCP-1) plays a key role in the recruitment of monocytes toward the peritoneal cavity. However, little is known about the effect of high glucose on MCP-1… CONTINUE READING
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