High glucose-induced expression of inflammatory cytokines and reactive oxygen species in cultured astrocytes.

@article{Wang2012HighGE,
  title={High glucose-induced expression of inflammatory cytokines and reactive oxygen species in cultured astrocytes.},
  author={Jiali Wang and G Li and Zhengyan Wang and Xiaoling Zhang and Longbiao Yao and F-w Wang and S-m Liu and Jiajing Yin and E. A. Ling and L-l Wang and A-j Hao},
  journal={Neuroscience},
  year={2012},
  volume={202},
  pages={58-68}
}
Astrocyte activation plays important roles both in physiological and pathological process in the CNS. In the latter, the process is further aggravated by hyperglycemia, leading to diabetes complications of CNS. We report here that high glucose (HG) treatment stimulated astrocytic morphological alteration coupled with changes in glial fibrillary acidic protein (GFAP) and vimentin expression. Additionally, HG upregulated the expression of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6… CONTINUE READING
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