High glucose-induced apoptosis through store-operated calcium entry and calcineurin in human umbilical vein endothelial cells.

@article{Tamareille2006HighGA,
  title={High glucose-induced apoptosis through store-operated calcium entry and calcineurin in human umbilical vein endothelial cells.},
  author={Sophie Tamareille and Olivier Mignen and Thierry Capiod and Catherine R{\"u}cker-Martin and Danielle Feuvray},
  journal={Cell calcium},
  year={2006},
  volume={39 1},
  pages={47-55}
}
Diabetes mellitus causes multiple cardiovascular complications. Previous studies have shown that prolonged exposure (96 h) of human umbilical vein endothelial cells (HUVECs) to hyperglycemia causes a significant increase in apoptosis. We report here that this increase in apoptosis is associated with an increase in Ca(2+) current (whole cell patch-clamp recorded) resulting from Ca(2+) entry mediated by store-operated channels (SOCs). The number of apoptotic cells after prolonged high glucose (HG… CONTINUE READING

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