High glucose-induced O-GlcNAcylated carbohydrate response element-binding protein (ChREBP) mediates mesangial cell lipogenesis and fibrosis: the possible role in the development of diabetic nephropathy.

@article{Park2014HighGO,
  title={High glucose-induced O-GlcNAcylated carbohydrate response element-binding protein (ChREBP) mediates mesangial cell lipogenesis and fibrosis: the possible role in the development of diabetic nephropathy.},
  author={Min-Jung Park and Dong-Il Kim and Seul-ki Lim and J Choi and H Han and Kyung Chul Yoon and Soo-Hyun Park},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 19},
  pages={13519-30}
}
Carbohydrate response element-binding protein (ChREBP) is a transcription factor responsible for carbohydrate metabolism in the liver. However, the role of ChREBP in diabetic nephropathy has not been elucidated. Thus, we investigated the role of ChREBP in mesangial cells in diabetic nephropathy. Treatment with 25 mM glucose (high glucose; HG) increased cellular O-GlcNAc and O-GlcNAcylated ChREBP in mesangial cells compared with normal 5.5 mM glucose. O-(2-acetamido-2-deoxy-D-glucopyranosylidene… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 47 references

The role of O-linked GlcNAc modification on the glucose response of ChREBP.

Biochemical and biophysical research communications • 2010
View 4 Excerpts
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