High glucose increases growth and collagen synthesis in cultured human tubulointerstitial cells.

@article{Jones1999HighGI,
  title={High glucose increases growth and collagen synthesis in cultured human tubulointerstitial cells.},
  author={Snake C. Jones and Heather J. Saunders and Carol A. Pollock},
  journal={Diabetic medicine : a journal of the British Diabetic Association},
  year={1999},
  volume={16 11},
  pages={932-8}
}
AIMS Altered proximal tubular cell growth and interstitial fibrosis are features of diabetic nephropathy and correlate with disease progression. These observations are poorly understood, although it has been suggested that they are secondary to glomerular disease. The primary aim of this study was to assess the direct effects of high extracellular glucose concentrations on the human tubulointerstitium. METHODS Primary cultures of human proximal tubule cells (PTCs) and cortical fibroblasts… CONTINUE READING

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The proximal tubule in the pathophysiology of the diabetic kidney.

American journal of physiology. Regulatory, integrative and comparative physiology • 2011
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