High glucose decreases endothelial cell proliferation via the extracellular signal regulated kinase/p15(INK4b) pathway.

@article{Chen2007HighGD,
  title={High glucose decreases endothelial cell proliferation via the extracellular signal regulated kinase/p15(INK4b) pathway.},
  author={Y Chen and J Y Guh and T Chuang and Hung-Chun Chen and Shean-jaw Chiou and Jau-Shyang Huang and Yulin Yang and Lea-Yea Chuang},
  journal={Archives of biochemistry and biophysics},
  year={2007},
  volume={465 1},
  pages={164-71}
}
High glucose inhibits endothelial cell proliferation. Thus, we studied cyclin-dependent kinase inhibitor p15(INK4b) in high glucose-induced effects in human umbilical endothelial cells at 24h. High glucose decreased cell proliferation while arresting cells in G(0)/G(1) phase of the cell cycle. High glucose increased phospho-extracellular signal regulated… CONTINUE READING