High glucose condition activates protein tyrosine phosphatases and deactivates insulin receptor function in insulin-sensitive rat 1 fibroblasts.

@article{Ide1994HighGC,
  title={High glucose condition activates protein tyrosine phosphatases and deactivates insulin receptor function in insulin-sensitive rat 1 fibroblasts.},
  author={Rie Ide and Hiroshi Maegawa and Ryuichi Kikkawa and Yukio Shigeta and Atsunori Kashiwagi},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={201 1},
  pages={71-7}
}
To investigate the mechanism for the impairment of insulin receptor kinase activity induced by high glucose (HG) in Rat 1 fibroblasts that expressed human insulin receptors (HIRc), we measured protein tyrosine phosphatase (PTPase) activity in HG cells. Incubating HIRc cells for 4 days in 27 mM D-glucose (HG) stimulated cytosolic PTPase activities, but not particulate PTPase activity as determined by two methods using the dephosphorylation of insulin receptors. Furthermore, PTP1B, a major non… CONTINUE READING

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