High glucose concentrations partially release hexokinase from inhibition by glucose 6-phosphate.

@article{Fujii1985HighGC,
  title={High glucose concentrations partially release hexokinase from inhibition by glucose 6-phosphate.},
  author={Setsuro Fujii and Ernest Beutler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 5},
  pages={1552-4}
}
The phosphorylation of glucose by human erythrocyte hexokinase follows classical Michaelis-Menten kinetics; hexokinase manifests maximum activity at 5 mM glucose, and no further increase in activity can be measured at higher glucose concentrations. However, the erythrocytes of diabetics and normal erythrocytes incubated with high concentrations of glucose contain increased concentrations of glucose 6-phosphate. To elucidate the mechanism of accumulation of glucose 6-phosphate when erythrocytes… CONTINUE READING