High glucose augments the angiotensin II-induced activation of JAK2 in vascular smooth muscle cells via the polyol pathway.

@article{Shaw2003HighGA,
  title={High glucose augments the angiotensin II-induced activation of JAK2 in vascular smooth muscle cells via the polyol pathway.},
  author={Sean S. Shaw and Xiaodan Wang and Heather Redd and Gwendolyn D Alexander and Carlos M. Isales and Mario B. Marrero},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 33},
  pages={30634-41}
}
Angiotensin II (Ang II), protein kinase C (PKC), reactive oxygen species (ROS) generated by NADPH oxidase, the activation of Janus kinase 2 (JAK2), and the polyol pathway play important parts in the hyperproliferation of vascular smooth muscle cells (VSMC), a characteristic feature of diabetic macroangiopathy. The precise mechanism, however, remains unclear. This study investigated the relation between the polyol pathway, PKC-beta, ROS, JAK2, and Ang II in the development of diabetic… CONTINUE READING

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