High glucose and insulin differentially modulates proliferation in MCF-7 and MDA-MB-231 cells.

@article{Gupta2013HighGA,
  title={High glucose and insulin differentially modulates proliferation in MCF-7 and MDA-MB-231 cells.},
  author={Chanchal Gupta and Kulbhushan Tikoo},
  journal={Journal of molecular endocrinology},
  year={2013},
  volume={51 1},
  pages={119-29}
}
Various preclinical and clinical studies have linked diabetes and breast cancer, but little is known regarding the molecular mechanism involved. This study aimed to investigate the effect of high glucose and insulin in breast cancer cells (MCF-7: non-invasive, hormone dependent, and MDA-MB-231: invasive, hormone independent). In contrast to MCF-7 cells, high glucose augmented proliferation of MDA-MB-231 cells as observed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and… CONTINUE READING
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