High glucose abolishes the antiproliferative effect of 17beta-estradiol in human vascular smooth muscle cells.

@article{Ling2002HighGA,
  title={High glucose abolishes the antiproliferative effect of 17beta-estradiol in human vascular smooth muscle cells.},
  author={Shanhong Ling and Peter J Little and Maro R I Williams and Aozhi Dai and Kazuhiko Hashimura and Jun Liu and Paul A Komesaroff and Krishnankutty Sudhir},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2002},
  volume={282 4},
  pages={E746-51}
}
We examined effects of 17beta-estradiol (E(2)) on human vascular smooth muscle cell (VSMC) proliferation under normal (5 mmol/l) and high (25 mmol/l) glucose concentrations. Platelet-derived growth factor (PDGF) BB (20 ng/ml)-induced increases in DNA synthesis and proliferation were greater in high than normal glucose concentrations; the difference in DNA synthesis was abolished by a protein kinase C (PKC)-beta inhibitor, LY-379196 (30 nmol/l). Western blotting showed that PKC-beta(1) protein… CONTINUE READING

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