High functional connectivity of tremor related subthalamic neurons in Parkinson’s disease

@article{Amtage2009HighFC,
  title={High functional connectivity of tremor related subthalamic neurons in Parkinson’s disease},
  author={Florian Amtage and Kathrin Henschel and Bj{\"o}rn Schelter and Jan Vesper and B. Hellwig},
  journal={Clinical Neurophysiology},
  year={2009},
  volume={120},
  pages={1755-1761}
}
OBJECTIVE Tremor is a core symptom of Parkinson's disease (PD). The subthalamic nucleus (STN) seems to be crucial for tremor pathophysiology considering that deep brain stimulation (DBS) of the STN leads to an effective reduction of Parkinsonian tremor. Here, we investigate the functional connectivity between STN neurons in patients with Parkinsonian tremor. METHODS STN activity was analyzed in 7 patients with Parkinsonian rest tremor who underwent stereotactic surgery for DBS. Spike activity… CONTINUE READING

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