High-fructose diet is as detrimental as high-fat diet in the induction of insulin resistance and diabetes mediated by hepatic/pancreatic endoplasmic reticulum (ER) stress

@article{Balakumar2016HighfructoseDI,
  title={High-fructose diet is as detrimental as high-fat diet in the induction of insulin resistance and diabetes mediated by hepatic/pancreatic endoplasmic reticulum (ER) stress},
  author={M. Balakumar and L. Raji and D. Prabhu and C. Sathishkumar and P. Prabu and V. Mohan and M. Balasubramanyam},
  journal={Molecular and Cellular Biochemistry},
  year={2016},
  volume={423},
  pages={93-104}
}
  • M. Balakumar, L. Raji, +4 authors M. Balasubramanyam
  • Published 2016
  • Biology, Medicine
  • Molecular and Cellular Biochemistry
  • In the context of high human consumption of fructose diets, there is an imperative need to understand how dietary fructose intake influence cellular and molecular mechanisms and thereby affect β-cell dysfunction and insulin resistance. While evidence exists for a relationship between high-fat-induced insulin resistance and metabolic disorders, there is lack of studies in relation to high-fructose diet. Therefore, we attempted to study the effect of different diets viz., high-fat diet (HFD… CONTINUE READING
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