High-fructose diet in pregnancy leads to fetal programming of hypertension, insulin resistance, and obesity in adult offspring.

@article{Saad2016HighfructoseDI,
  title={High-fructose diet in pregnancy leads to fetal programming of hypertension, insulin resistance, and obesity in adult offspring.},
  author={Antonio F. Saad and Joshua Dickerson and Talar B Kechichian and Huaizhi Yin and Phyllis K Gamble and Ashley E Salazar and Igor A Patrikeev and Massoud Motamedi and George R. Saade and Maged M. Costantine},
  journal={American journal of obstetrics and gynecology},
  year={2016},
  volume={215 3},
  pages={378.e1-6}
}
BACKGROUND Consumption of fructose-rich diets in the United States is on the rise and thought to be associated with obesity and cardiometabolic diseases. OBJECTIVE We sought to determine the effects of antenatal exposure to high-fructose diet on offspring's development of metabolic syndrome-like phenotype and other cardiovascular disease risk factors later in life. STUDY DESIGN Pregnant C57BL/6J dams were randomly allocated to fructose solution (10% wt/vol, n = 10) or water (n = 10) as the… CONTINUE READING
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