High frequency stimulation and temporary inactivation of the subthalamic nucleus reduce quinpirole-induced compulsive checking behavior in rats

@article{Winter2008HighFS,
  title={High frequency stimulation and temporary inactivation of the subthalamic nucleus reduce quinpirole-induced compulsive checking behavior in rats},
  author={Christine Winter and Adrian P. Mundt and Rafed Arne Jalali and Daphna Joel and Andreas Kupsch},
  journal={Experimental Neurology},
  year={2008},
  volume={210},
  pages={217-228}
}
Obsessive-compulsive disorder (OCD) represents a highly prevalent and impairing psychiatric disorder. Functional and structural imaging studies implicate the involvement of basal ganglia-thalamo-cortical circuits in the pathophysiology of this disorder. In patients remaining resistant to pharmaco- and behavioral therapy, modulation of these circuits may consequently reverse clinical symptoms. High frequency stimulation (HFS) of the subthalamic nucleus (STN), an important station of the basal… CONTINUE READING
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High-frequency stimulation of the nucleus accumbens core and shell reduces quinpirole-induced compulsive checking in rats.

  • The European journal of neuroscience
  • 2009
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