High-frequency oscillation in early acute respiratory distress syndrome.

@article{Ferguson2013HighfrequencyOI,
  title={High-frequency oscillation in early acute respiratory distress syndrome.},
  author={Niall D Ferguson and Deborah J Cook and Gordon H. Guyatt and Sangeeta Mehta and Lori E Hand and Peggy Austin and Qi Zhou and Andrea L. Matt{\'e} and Stephen D. Walter and François Lamontagne and John T Granton and Yaseen M Arabi and Alejandro C Arroliga and Thomas E. Stewart and Arthur S Slutsky and Maureen O. Meade},
  journal={The New England journal of medicine},
  year={2013},
  volume={368 9},
  pages={795-805}
}
BACKGROUND Previous trials suggesting that high-frequency oscillatory ventilation (HFOV) reduced mortality among adults with the acute respiratory distress syndrome (ARDS) were limited by the use of outdated comparator ventilation strategies and small sample sizes. METHODS In a multicenter, randomized, controlled trial conducted at 39 intensive care units in five countries, we randomly assigned adults with new-onset, moderate-to-severe ARDS to HFOV targeting lung recruitment or to a control… CONTINUE READING
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