High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia.

@article{Romana1995HighFO,
  title={High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia.},
  author={Serge Pierrick Romana and H{\'e}l{\`e}ne A. Poirel and M Leconiat and Maria Flexor and Martine Mauchauff{\'e} and Philippe Jonveaux and Elisabeth A Macintyre and Roland Berger and Olivier A. Bernard},
  journal={Blood},
  year={1995},
  volume={86 11},
  pages={
          4263-9
        }
}
The recurrent t(12;21)(p12;q22) translocation fuses two genes, TEL and AML1, that have previously been shown to be independently involved in myeloid malignant proliferations. A search for rearrangement of the TEL locus in the region known to be involved in t(12;21) was performed by Southern blotting in a panel of hematopoietic malignancies. The presence of a t(12;21) was confirmed by fluorescence in situ hybridization (FISH) and/or reverse transcriptase (RT)-polymerase chain reaction (PCR). We… CONTINUE READING

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