High frequency of submicroscopic genomic aberrations detected by tiling path array comparative genome hybridisation in patients with isolated congenital heart disease.

@article{Erdogan2008HighFO,
  title={High frequency of submicroscopic genomic aberrations detected by tiling path array comparative genome hybridisation in patients with isolated congenital heart disease.},
  author={Fikret Erdogan and Lars Allan Larsen and Lusi Zhang and Zeynep T{\"u}mer and Niels Tommerup and Wei Chen and Joes Rams\oe Jacobsen and Marion Schubert and Jan Jurkatis and Andreas Tzschach and H Hilger Ropers and Reinhard Ullmann},
  journal={Journal of medical genetics},
  year={2008},
  volume={45 11},
  pages={704-9}
}
BACKGROUND Congenital heart disease (CHD) is the most common birth defect and affects nearly 1% of newborns. The aetiology of CHD is largely unknown and only a small percentage can be assigned to environmental risk factors such as maternal diseases or exposure to mutagenic agents during pregnancy. Chromosomal imbalances have been identified in many forms of syndromic CHD, but very little is known about the impact of DNA copy number changes in non-syndromic CHD. METHOD A sub-megabase… CONTINUE READING