High frequency of streptococcal bacteraemia during childhood AML therapy irrespective of dose of cytarabine

@article{Johannsen2013HighFO,
  title={High frequency of streptococcal bacteraemia during childhood AML therapy irrespective of dose of cytarabine},
  author={K.-. Johannsen and Mette M{\o}ller Handrup and Birgitte Lausen and Henrik Daa Schr{\o}der and Henrik Hasle},
  journal={Pediatric Blood \& Cancer},
  year={2013},
  volume={60}
}
BACKGROUND High-dose cytarabine has been associated with a high frequency of viridans group streptococcal (VGS) bacteraemia. [] Key MethodPROCEDURE Medical records of all Danish children enrolled on the NOPHO-AML-2004 protocol between January 2004 and September 2011 (n = 45) were retrospectively reviewed and all febrile episodes were registered. RESULTS Following 236 courses of chemotherapy, 112 positive blood cultures were registered. VGS were found in 38% of all positive blood cultures. Infectious…
View on Wiley
slaop.org
22 Citations
Background Citations
8
Results Citations
3

22 Citations

Citation Type

Citation Type

Viridans Group Streptococcal Infections in Children After Chemotherapy or Stem Cell Transplantation
TLDR
Research is needed to develop risk-stratification scores that identify children at risk of Viridans Group Streptococcal Shock Syndrome to guide empirical antimicrobial therapy in febrile neutropenia.
Temporal changes in neutropenic blood culture isolates and disease associations: a single centre series of 1139 episodes
TLDR
Positive associations were found between viridans streptococci and acute myeloid leukaemia, coagulase negative staphylococCI and acute lymphoblasticLeukaemia and Pseudomonas aeruginosa and indolent B‐cell malignancies.
Clinical and Microbiologic Outcomes of Quinolone Prophylaxis in Children With Acute Myeloid Leukemia
TLDR
The use of ciprofloxacin prophylaxis (CPx) in children with pediatric acute myeloid leukemia did not alter the incidence of overall bacteremia nor change the pattern of fever or use of supportive care, and this experience supports further investigation into the use of extended-spectrum quinolone proPHylaxis during therapy for pediatric AML.
Antibiotic prophylaxis with teicoplanin on alternate days reduces rate of viridans sepsis and febrile neutropenia in pediatric patients with acute myeloid leukemia
TLDR
Antibiotic prophylaxis with teicoplanin (or vancomycin) appears safe and feasible and resulted in eradication of viridans sepsis and decreased incidence of febrile neutropenia in pediatric AML patients.
Infectious Prophylaxis in Paediatric Oncology and Stem Cell Transplantation
TLDR
Questions remain as to the optimal approach to infectious prophylaxis using currently available agents and there is a clear need for further directed paediatric research in this area.
Infectious Complications in Children With Acute Myeloid Leukemia and Down Syndrome: Analysis of the Prospective Multicenter Trial AML‐BFM 2004
Children with acute myeloid leukemia (AML) and Down syndrome have high survival rates with intensity‐reduced chemotherapeutic regimens, although the optimal balance between dose intensity and…
Strategies for reducing the treatment‐related physical burden of childhood acute myeloid leukaemia – a review
TLDR
Analysing scenarios with different frequency of transplantation in first complete remission show similar overall survival rates, indicating that almost all patients can be spared the procedure in first remission.
Bacterial Infections in Children With Acute Myeloid Leukemia Receiving Ciprofloxacin Prophylaxis
TLDR
A high rate of bacterial infection was detected in patients who received the AML02 protocol, mainly gram-positive bacterial infections, which should be reconsidered for its efficacy, and other antibacterial prophylaxis may be used.
Differences in infection prophylaxis measures between paediatric acute myeloid leukaemia study groups within the international Berlin–Frankfürt–Münster (I‐BFM) study group
TLDR
Using a web‐based survey, the infection prophylaxis guidelines of 22 paediatric AML study groups affiliated to the international Berlin–Frankfürt–Münster study group are investigated, finding many differences are still present between the affiliated groups.
Surveillance of bloodstream infections in pediatric cancer centers – what have we learned and how do we move on?
TLDR
The epidemiology and the distinct pathogen profile of BSI in pediatric cancer patients from the perspective of infection surveillance are summarized and problems in executing the current surveillance definition in this patient population are discussed.
...
1
2
3
...

References

SHOWING 1-10 OF 28 REFERENCES
Low incidence of sepsis due to viridans streptococci in a ten‐year retrospective study of pediatric acute myeloid leukemia
TLDR
Assessment of the frequency and characteristics of infectious complications, the incidence of VGS sepsis, the interest of preventive decontamination, and a possible cytarabine dose‐effect on the occurrence of ICs in children with AML sought.
Infections with viridans group streptococci in children with cancer
TLDR
Current recommendations include appropriate antibiotic therapy and intensive supportive care against VGS infection, which may be accompanied by neurological complications, myocarditis, and acute respiratory distress syndrome.
High-dose cytosine arabinoside and viridans streptococcus sepsis in children with leukemia.
TLDR
The prompt empiric use of a glycopeptide antibiotic in addition to the conventional association of a beta-lactam plus an aminoglycoside may significantly decrease the mortality rate due to fulminant streptococci sepsis while the patient is severely neutropenic.
Viridans group streptococcal infections among children with cancer and the importance of emerging antibiotic resistance.
TLDR
An overview of Viridans group streptococci, a description of the clinical spectrum of VGS-related diseases in children with cancer, and the recent data regarding the incidence, clinical significance, and management of emerging antibiotic resistance among VGS are presented.
Infections in patients with febrile neutropenia: epidemiology, microbiology, and risk stratification.
  • C. Viscoli, O. Varnier, M. Machetti
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2005
Determinations of the type and setting of empirical therapy for immunocompromised patients with fever are complicated by the characteristics of the underlying illness and the effects of treatments…
Bacteremia due to viridans streptococci in neutropenic patients: a review.
Viridans streptococci bacteraemia in children with fever and neutropenia: a case-control study of predisposing factors.
Prophylactic antibiotics reduce morbidity due to septicemia during intensive treatment for pediatric acute myeloid leukemia
The aim of this study was to determine whether antibiotic prophylaxis during periods of neutropenia reduced streptococcal (S. viridans) sepsis and overall bacterial sepsis.
Alpha hemolytic streptococcal infection during intensive treatment for acute myeloid leukemia: a report from the Children's cancer group study CCG-2891.
TLDR
This study, the first to prospectively examine AHS incidence among uniformly treated patients in multiple institutions, established that as the intensity of AML therapy has increased, so has the rate of AHS.
DECREASED INCIDENCE OF VIRIDANS STREPTOCOCCAL SEPTICAEMIA IN ALLOGENEIC BONE MARROW TRANSPLANT RECIPIENTS AFTER THE INTRODUCTION OF ACYCLOVIR
...
1
2
3
...