High frequency of rare alleles of the human c-Ha-ras-1 proto-oncogene in breast cancer patients.

The c-Ha-ras-1 locus in 104 breast cancer patients and 56 unaffected individuals was examined for allelic restriction fragment-length polymorphism. Four common and 16 rare alleles were detected in the combined populations. The distribution of common and rare alleles differed significantly between the two populations. The common restriction fragments… CONTINUE READING