High frequency of mutations of the PIK3CA gene in human cancers.

  title={High frequency of mutations of the PIK3CA gene in human cancers.},
  author={Yardena Samuels and Zhenghe Wang and Alberto Bardelli and Natalie Silliman and Janine Ptak and Steve Szabo and Hai Yan and Adi Gazdar and Steven M. Powell and Gregory Joseph Riggins and James K. V. Willson and Sanford D Markowitz and Kenneth W. Kinzler and Bert Vogelstein and Victor E. Velculescu},
  volume={304 5670},
Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate signaling pathways important for neoplasia, including cell proliferation, adhesion, survival, and motility (1–3). To determine if PI3Ks are genetically altered in tumorigenesis, we sequenced PI3K genes in human cancers and corresponding normal tissue. Hidden Markov models were used to identify eight PI3K and eight PI3K-like genes, including two uncharacterized genes, in the human genome (3) (table S1). We initially examined… CONTINUE READING
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