High frequency of mutations in MODY and mitochondrial genes in Scandinavian patients with familial early-onset diabetes

@article{Lehto1999HighFO,
  title={High frequency of mutations in MODY and mitochondrial genes in Scandinavian patients with familial early-onset diabetes},
  author={Markku Lehto and C. Wipemo and S Ivarsson and Cecilia Lindgren and Marita Lipsanen-Nyman and Jianping Weng and L B Wibell and Elisabeth Wid{\'e}n and Tiinamaija Tuomi and Leif Groop},
  journal={Diabetologia},
  year={1999},
  volume={42},
  pages={1131-1137}
}
Aims/hypothesis. To investigate the contribution of mutations in maturity-onset diabetes of the young (MODY) and mitochondrial genes to early-onset diabetes with a strong family history of diabetes in a cohort with a high prevalence of Type I (insulin-dependent) diabetes mellitus. Methods. Screening for sequence variants in the hepatocyte nuclear factor (HNF)–4 α (MODY1), glucokinase (MODY2), HNF-1 α (MODY3) genes and mitochondrial DNA was carried out in 115 Finnish and Swedish patients with… CONTINUE READING
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Heterogeneity in Type 2 diabetes: Lessons from maturity-onset diabetes of the young

  • AT Hattersley
  • Diabetic Reviews International
  • 1998
Highly Influential
5 Excerpts

Mutation in the HNF-4a gene affects insulin secretion and triglyceride metabolism

  • M Lehto, P-O BitzØn, B Isomaa
  • Diabetes
  • 1999
2 Excerpts

Mutations in the hepatocyte nuclear factor - 1 a gene in Caucasian families originally classified as having Type I diabetes

  • MA Glucksmann, M Lehto, O Tayber
  • Diabetologia
  • 1998

of the young in Japanese subjects

  • F Beards, T Frayling, M Bulman
  • 1998

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