High frequency of hotspot mutations in core genes of Escherichia coli due to short-term positive selection.

@article{Chattopadhyay2009HighFO,
  title={High frequency of hotspot mutations in core genes of Escherichia coli due to short-term positive selection.},
  author={Sujay Chattopadhyay and Scott J. Weissman and Vladimir N. Minin and Thomas A. Russo and Daniel E. Dykhuizen and Evgeni V. Sokurenko},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 30},
  pages={12412-7}
}
Core genes comprising the ubiquitous backbone of bacterial genomes are not subject to frequent horizontal transfer and generally are not thought to contribute to the adaptive evolution of bacterial pathogens. We determined, however, that at least one-third and possibly more than one-half of the core genes in Escherichia coli genomes are targeted by repeated replacement substitutions in the same amino acid positions-hotspot mutations. Occurrence of hotspot mutations is driven by positive… CONTINUE READING

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