High frequency of clonal immunoglobulin receptor gene rearrangements in sporadic histiocytic/dendritic cell sarcomas.

@article{Chen2009HighFO,
  title={High frequency of clonal immunoglobulin receptor gene rearrangements in sporadic histiocytic/dendritic cell sarcomas.},
  author={Wei Chen and Sean K. Lau and Dean Fong and Jun Wang and Endi Wang and Daniel Alan Arber and Lawrence M. Weiss and Qin Huang},
  journal={The American journal of surgical pathology},
  year={2009},
  volume={33 6},
  pages={863-73}
}
The diagnosis of histiocytic/dendritic cell (H/DC) sarcomas is currently based on morphology and the presence of immunophenotypic features of H/DC differentiation. The issue whether clonal immunoglobulin receptor gene rearrangements are present in H/DC sarcomas has been debated over decades until the recent data by Feldman et al, which provided compelling evidence that patients with follicular lymphoma and concurrent/synchronous H/DC sarcoma share identical genotypic features, suggested the… CONTINUE READING
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