High frequency of activated K-ras codon 15 mutant in colorectal carcinomas from Taiwanese patients.

@article{Wang2003HighFO,
  title={High frequency of activated K-ras codon 15 mutant in colorectal carcinomas from Taiwanese patients.},
  author={Jaw-Yuan Wang and J L Hsieh and F. Chen and Ching-Sheng Yeh and Ketil Alexandersen and Tsung-Jen Huang and David P. Chen and S Lin},
  journal={International journal of cancer},
  year={2003},
  volume={107 3},
  pages={387-93}
}
Colorectal carcinogenesis is regarded as a multistep process resulting from accumulation of genetic alterations, including activation of protooncogenes and inactivation of tumor suppressor genes via signal transduction trigger the stage-wise progression to malignancy. The reported incidence of K-ras mutation detected in general tissue samples ranges from 21-60% in primary colorectal cancers (CRC). To assess the prevalence and spectrum of K-ras mutations in Taiwanese patients with CRC, we… CONTINUE READING

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