High frequency of IDH-1 mutation links glioneuronal tumors with neuropil-like islands to diffuse astrocytomas

@inproceedings{Huse2011HighFO,
  title={High frequency of IDH-1 mutation links glioneuronal tumors with neuropil-like islands to diffuse astrocytomas},
  author={Jason T Huse and Kh{\'e}doudja Nafa and Neerav N Shukla and Edward R. Kastenhuber and Ehud Lavi and Cyrus V. Hedvat and Marc Ladanyi and Marc K. Rosenblum},
  booktitle={Acta Neuropathologica},
  year={2011}
}
The glioneuronal tumor with neuropil-like islands (GTNI) is an uncommon histopathological entity composed of diffuse astrocytic or oligoastrocytic elements interspersed with sharply delimited, micronodular loci of neuronal differentiation. Despite its initial description over 10 years ago [10], the lineage classification of GTNI remains speculative. The clinical features of GTNI, its infiltrative growth characteristics, typically dominating astroglial components, and frequent p53 expression… CONTINUE READING