High frequency of Epstein-Barr virus genome detection in Hodgkin's disease of HIV-positive patients.

@article{Uccini1990HighFO,
  title={High frequency of Epstein-Barr virus genome detection in Hodgkin's disease of HIV-positive patients.},
  author={Stefania Uccini and Francesca Monardo and Antonella Stoppacciaro and Angela Gradilone and Anna Maria Aglian{\`o} and Alberto Faggioni and Vittorio Manzari and Luca Vago and Giulio Costanzi and Luigi P. Ruco},
  journal={International journal of cancer},
  year={1990},
  volume={46 4},
  pages={581-5}
}
Lymph nodes obtained from 7 HIV-positive and 20 HIV-negative patients with Hodgkin's disease were examined for the presence of Epstein-Barr virus antigens and genome. EBV antigens were observed in only 2 out of 20 HIV-negative patients, whereas lymph nodes of HIV-positive patients did not reveal evidence of EBV antigens. By in situ hybridization and Southern blot analysis, EBV genome was found in 5 out of 7 HIV-positive patients; the EBV genome was detected in the nucleus of Reed-Sternberg and… CONTINUE READING

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