High-frequency irreversible electroporation (H-FIRE) for non-thermal ablation without muscle contraction

BACKGROUND Therapeutic irreversible electroporation (IRE) is an emerging technology for the non-thermal ablation of tumors. The technique involves delivering a series of unipolar electric pulses to permanently destabilize the plasma membrane of cancer cells through an increase in transmembrane potential, which leads to the development of a tissue lesion… CONTINUE READING