High-frequency intracellular invasion of epithelial cells by serotype M1 group A streptococci: M1 protein-mediated invasion and cytoskeletal rearrangements.

@article{Dombek1999HighfrequencyII,
  title={High-frequency intracellular invasion of epithelial cells by serotype M1 group A streptococci: M1 protein-mediated invasion and cytoskeletal rearrangements.},
  author={Priscilla E Dombek and David Cue and Jerry Sedgewick and Hubert Lam and S R Ruschkowski and B Brett Finlay and Patrick P. Cleary},
  journal={Molecular microbiology},
  year={1999},
  volume={31 3},
  pages={859-70}
}
A clonal variant of serotype M1 group A streptococcus (designated M1inv+) has been linked to severe and invasive infections, including sepsis, necrotizing fasciitis and toxic shock. High frequency internalization of cultured epithelial cells by the M1inv+ strain 90-226 is dependent upon the M1 protein. Invasion of HeLa cells was blocked by an anti-M1 antibody, invasion by an M1- strain (90-226 emm1::km) was greatly reduced, and latex beads bound to M1 protein were readily internalized by HeLa… CONTINUE READING

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