High-frequency generation of viable mice from engineered bi-maternal embryos

  title={High-frequency generation of viable mice from engineered bi-maternal embryos},
  author={M. Kawahara and Q. Wu and Nozomi Takahashi and S. Morita and Kaori Yamada and Mitsuteru Ito and A. Ferguson-Smith and T. Kono},
  journal={Nature Biotechnology},
  • M. Kawahara, Q. Wu, +5 authors T. Kono
  • Published 2007
  • Biology, Medicine
  • Nature Biotechnology
  • Mammalian development to adulthood typically requires both maternal and paternal genomes, because genomic imprinting places stringent limitations on mammalian development, strictly precluding parthenogenesis. Here we report the generation of bi-maternal embryos that develop at a high success rate equivalent to the rate obtained with in vitro fertilization of normal embryos. These bi-maternal mice developed into viable and fertile female adults. The bi-maternal embryos, distinct from… CONTINUE READING

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