High-frequency generation of new immunoresistant tumor variants during metastasis of a cloned murine tumor line (ESb).


A metastatic variant of a chemically induced lymphoma (ESb) from a DBA/2 mouse was found to activate in syngeneic hosts specific anti-tumor cytolytic T lymphocytes (CTL) which recognized on the tumor a distinct tumor-associated antigen. Upon metastasis of a cloned ESb tumor line from an s.c. site to the spleen, the tumor cells which were originally… (More)


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