High-frequency generation of conditional mutations affecting Drosophila melanogaster development and life span.

  title={High-frequency generation of conditional mutations affecting Drosophila melanogaster development and life span.},
  author={Gary N. Landis and Deepak Bhole and Ling Lu and J. E. Tower},
  volume={158 3},
Genome sequencing reveals that a large percentage of Drosophila genes have homologs in humans, including many human disease genes. The goal of this research was to develop methods to efficiently test Drosophila genes for functions in vivo. An important challenge is the fact that many genes function at more than one point during development and during the life cycle. Conditional expression systems such as promoters regulated by tetracycline (or its derivative doxycycline) are often ideal for… CONTINUE READING

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