High frequency deep brain stimulation: what are the therapeutic mechanisms?

@article{Liu2008HighFD,
  title={High frequency deep brain stimulation: what are the therapeutic mechanisms?},
  author={Ying Liu and Nadia O. Postupna and J. Haakon Falkenberg and Marjorie E. Anderson},
  journal={Neuroscience and biobehavioral reviews},
  year={2008},
  volume={32 3},
  pages={343-51}
}
High frequency deep brain stimulation (HFS) used to treat the symptoms of Parkinson's disease (PD) was first assumed to act by reducing an excessive tonic GABAergic inhibitory output from the internal globus pallidus (GPi). Stimulation in GPi might produce this directly by mechanisms such as depolarization block or activation of presynaptic inhibitory fibers, and the same mechanisms evoked by HFS in the subthalamic nucleus (STN) could reduce the excitatory action of STN on GPi neurons. Although… CONTINUE READING

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