High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor.

@article{Krzywkowski2008HighfrequencyHV,
  title={High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor.},
  author={Karen M Krzywkowski and Paul A. Davies and Paula Leslie Feinberg-Zadek and Hans Br{\"a}uner-Osborne and Anders A Jensen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 2},
  pages={
          722-7
        }
}
The 5-hydroxytryptamine-3 (5-HT3) receptor mediates the fast excitatory neurotransmission of serotonin and is known to mediate the nausea/emesis induced by radio/chemotherapy and anesthetics. A polymorphism encoding the variation Y129S in the 5-HT3B subunit exists in high frequency in the general population and has been shown to be inversely correlated to the incidence of major depression in women. We show that 5-HT3AB(Y129S) receptors exhibit a substantially increased maximal response to… CONTINUE READING
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