High frequencies of alleles MICA*020 and MICA*027 in Amerindians and evidence of positive selection on exon 3

@article{Oliveira2008HighFO,
  title={High frequencies of alleles MICA*020 and MICA*027 in Amerindians and evidence of positive selection on exon 3},
  author={Laser Am Oliveira and Fernanda Marcondes Ribas and Maria da Graça Bicalho and Luiza Tamie Tsuneto and Maria Luiza Petzl-Erler},
  journal={Genes and Immunity},
  year={2008},
  volume={9},
  pages={697-705}
}
MICA is a nonclassical polymorphic MHC molecule. We investigated MICA allelic frequencies and MICA–HLA-B–HLA-C haplotypes in Brazilian Amerindians to describe the polymorphism and to extract information about the evolution of MICA gene. Kaingang is the first population described to have a high frequency of MICA*020, found associated with HLA-B*3505–HLA-Cw*0401. Allele MICA*020 probably originated de novo in South America. The Guarani population had high frequencies of MICA*027. Allele MICA… CONTINUE READING