High frequencies of alleles MICA*020 and MICA*027 in Amerindians and evidence of positive selection on exon 3


MICA is a nonclassical polymorphic MHC molecule. We investigated MICA allelic frequencies and MICA–HLA-B–HLA-C haplotypes in Brazilian Amerindians to describe the polymorphism and to extract information about the evolution of MICA gene. Kaingang is the first population described to have a high frequency of MICA*020, found associated with HLA-B*3505–HLA-Cw… (More)
DOI: 10.1038/gene.2008.65


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