High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells.

@article{Pellis2008HighFA,
  title={High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells.},
  author={Linette P Pellis and Yvonne E M Dommels and Dini Venema and Ab van Polanen and Esther H. Lips and Hakan Baykus and Frans J. Kok and Ellen Kampman and Jaap Keijer},
  journal={The British journal of nutrition},
  year={2008},
  volume={99 4},
  pages={703-8}
}
Folate, a water-soluble B vitamin, is a cofactor in one-carbon metabolism and is essential for DNA synthesis, amino acid interconversion, methylation and, consequently, normal cell growth. In animals with existing pre-neoplastic and neoplastic lesions, folic acid supplementation increases the tumour burden. To identify processes that are affected by increased folic acid levels, we compared HT29 human colon cancer cells exposed to a chronic supplemental (100 ng/ml) level of folic acid to cells… CONTINUE READING
12 Citations
47 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Similar Papers

Loading similar papers…