High-flow nasal cannula therapy for children with bronchiolitis: a systematic review and meta-analysis

@article{Lin2019HighflowNC,
  title={High-flow nasal cannula therapy for children with bronchiolitis: a systematic review and meta-analysis},
  author={Jilei Lin and Yin Zhang and Limei Xiong and Sha Liu and Cai-hui Gong and Jihong Dai},
  journal={Archives of Disease in Childhood},
  year={2019},
  volume={104},
  pages={564 - 576}
}
Objectives To review the effects and safety of high-flow nasal cannula (HFNC) for bronchiolitis. Methods Six electronic databases including PubMed, EMBASE, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, CQ VIP Database and Wanfang Data were searched from their inception to 1 June 2018. Randomised controlled trials (RCTs) which investigated the effects of HFNC versus other forms of oxygen therapies for bronchiolitis were included. Results Nine RCTs with… 
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67 Citations
Highly Influential Citations
1
Background Citations
8
Methods Citations
2

67 Citations

The Effects and Safety of Continuous Positive Airway Pressure in Children with Bronchiolitis: A Systematic Review and Meta-Analysis.

CPAP for the initial respiratory management significantly benefit children with bronchiolitis, the delivery of CPAP by helmet may be a better choice, and more high-quality research is needed to confirm the conclusion.

Efficacy and safety of high flow nasal oxygen for children with bronchiolitis: systematic review and meta-analysis

HFNC is superior to SOT in terms of treatment failure and there is no significant difference between HFNC and CPAP in termsof treatment failure, which suggest HFNC is safe to use in acute hospital settings.

High‐flow oxygen in bronchiolitis

  • Medicine
    Journal of paediatrics and child health
  • 2019
High-flow nasal cannula oxygen is less invasive than CPAP and can be a useful intervention for babies who need more than standard oxygen treatment but do not yet need CPAP or more invasive ventilation.

High-Flow Oxygen and Other Noninvasive Respiratory Support Therapies in Bronchiolitis: Systematic Review and Network Meta-Analyses.

Experimental evidence does not suggest that high-flow oxygen therapy has advantages over LFOT as initial treatment nor over NIV as a rescue treatment, and the included studies show methodological heterogeneity, but it is only statistically significant for the reduction of days of oxygen therapy and length of hospital stay.

Continuous Positive Airway Pressure vs. High Flow Nasal Cannula in children with acute severe or moderate bronchiolitis. A systematic review and Meta-analysis.

Continuous Positive Airway Pressure vs. High Flow Nasal Cannula in children with acute severe or moderate bronchiolitis. A systematic review and Meta-analysis.

High-Flow Nasal Cannula versus Continuous Positive Airway Pressure in Critical Bronchiolitis: A Randomized Controlled Pilot.

In this pilot study, treatment with HFNC resulted in a rate of treatment failure similar to CPAP, and Pediatric intensive care unit length of stay was similar between the CPAP and HFNC groups.

The nutritional impact of a feeding protocol for infants on high flow nasal cannula therapy.

The use of a feeding protocol for patients with bronchiolitis on HFNC was safe and associated with shorter time to initiate EN and shorter length of hospital stay.

Outcomes of High-Flow Nasal Cannula Vs. Nasal Continuous Positive Airway Pressure in Young Children With Respiratory Distress: A Systematic Review and Meta-Analysis

Among children with respiratory distress younger than 2 years, HFNC appears to be associated with higher risk of treatment failure and possibly, an increased risk of need for intubation and mortality.

Clinical factors associated with intubation in the high flow nasal cannula era.

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References

SHOWING 1-10 OF 43 REFERENCES

High flow therapy versus hypertonic saline in bronchiolitis: randomised controlled trial

Objective To demonstrate that heated humidified high-flow nasal cannula (HHHFNC) is superior to inhaled hypertonic saline solution (HSS) in improving respiratory distress in moderate bronchiolitis.…

High flow therapy versus hypertonic saline in bronchiolitis: randomised controlled trial

Objective To demonstrate that heated humidified high-flow nasal cannula (HHHFNC) is superior to inhaled hypertonic saline solution (HSS) in improving respiratory distress in moderate bronchiolitis.…

Clinical application of heated, humidified high-flow nasal cannula in the treatment of moderate and severe bronchiolitis in infants

The efficacy and security of HHFNC on moderate and severe bronchiolitis are better than those of nCPAP, and it is recommended for clinical application widely.

High-flow nasal cannula therapy for infants with bronchiolitis.

The current evidence is of low quality, from one small study with uncertainty about the estimates of effect and an unclear risk of performance and detection bias, and the included study provides some indication that HFNC therapy is feasible and well tolerated.

A Randomized Trial of High‐Flow Oxygen Therapy in Infants with Bronchiolitis

Among infants with bronchiolitis who were treated outside an ICU, those who received high‐flow oxygen therapy had significantly lower rates of escalation of care due to treatment failure than those in the group that received standard oxygen therapy.

Reduced intubation rates for infants after introduction of high-flow nasal prong oxygen delivery

HFNP therapy has dramatically changed ventilatory practice in infants <24 months of age in this institution, and appears to reduce the need for intubation in infants with viral bronchiolitis.

Comparison of CPAP and HFNC in Management of Bronchiolitis in Infants and Young Children

CPAP was more effective than HFNC in decreasing respiratory rate (RR) and FiO2 and no differences were observed in length of treatment or complications.

Nasopharyngeal Airway Pressures in Bronchiolitis Patients Treated With High-Flow Nasal Cannula Oxygen Therapy

Increasing flow rates of HHHFNC therapy are associated with linear increases in NP pressures in bronchiolitis patients, and only flow (not weight or gender) had an effect on generated pressure.

High flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: a multicenter randomized controlled trial (TRAMONTANE study)

In young infants with moderate to severe AVB, initial management with HFNC did not have a failure rate similar to that of nCPAP, and the success rate with the alternative respiratory support, intubation rate, durations of noninvasive and invasive ventilation, skin lesions, and length of PICU stay were comparable between groups.

Improved clinical and economic outcomes in severe bronchiolitis with pre-emptive nCPAP ventilatory strategy

PurposeSevere bronchiolitis is the leading cause of admission to the pediatric intensive care unit (PICU). Nasal continuous positive airway pressure (nCPAP) has become the primary respiratory…