High-field MRS study of GABA, glutamate and glutamine in social anxiety disorder: Response to treatment with levetiracetam

  title={High-field MRS study of GABA, glutamate and glutamine in social anxiety disorder: Response to treatment with levetiracetam},
  author={M. Pollack and J. E. Jensen and N. Simon and Rebecca E. Kaufman and P. Renshaw},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  • M. Pollack, J. E. Jensen, +2 authors P. Renshaw
  • Published 2008
  • Psychology, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • OBJECTIVE Abnormalities in brain gamma-aminobutyric acid (GABA) and glutamate may be relevant to the underlying pathophysiology of anxiety disorders including social anxiety disorder (SAD). METHODS We used proton magnetic resonance spectroscopy (pMRS) to examine whole brain and regional GABA, glutamate and glutamine in patients (N=10) with SAD at baseline compared to a matched group of healthy controls (HC), and changes following 8 weeks of pharmacotherapy with levetiracetam. RESULTS For… CONTINUE READING
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