High fidelity simian immunodeficiency virus reverse transcriptase mutants have impaired replication in vitro and in vivo.

@article{Lloyd2016HighFS,
  title={High fidelity simian immunodeficiency virus reverse transcriptase mutants have impaired replication in vitro and in vivo.},
  author={Sarah B Lloyd and Marit Lichtfuss and Thakshila Amarasena and Sheilajen Alc{\^a}ntara and Robert A De Rose and Gilda Tachedjian and Hamid Alinejad-Rokny and Vanessa Venturi and Miles P. Davenport and Wendy R. Winnall and Stephen J Kent},
  journal={Virology},
  year={2016},
  volume={492},
  pages={1-10}
}
The low fidelity of HIV replication facilitates immune and drug escape. Some reverse transcriptase (RT) inhibitor drug-resistance mutations increase RT fidelity in biochemical assays but their effect during viral replication is unclear. We investigated the effect of RT mutations K65R, Q151N and V148I on SIV replication and fidelity in vitro, along with SIV… CONTINUE READING