High-fat diets cause insulin resistance despite an increase in muscle mitochondria.

Abstract

It has been hypothesized that insulin resistance is mediated by a deficiency of mitochondria in skeletal muscle. In keeping with this hypothesis, high-fat diets that cause insulin resistance have been reported to result in a decrease in muscle mitochondria. In contrast, we found that feeding rats high-fat diets that cause muscle insulin resistance results… (More)
DOI: 10.1073/pnas.0802057105

Topics

5 Figures and Tables

Blog articles referencing this paper

Slides referencing similar topics