High-fat diets cause insulin resistance despite an increase in muscle mitochondria.


It has been hypothesized that insulin resistance is mediated by a deficiency of mitochondria in skeletal muscle. In keeping with this hypothesis, high-fat diets that cause insulin resistance have been reported to result in a decrease in muscle mitochondria. In contrast, we found that feeding rats high-fat diets that cause muscle insulin resistance results… (More)
DOI: 10.1073/pnas.0802057105


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