High-fat diet without excess calories induces metabolic disorders and enhances atherosclerosis in rabbits.

@article{Waqar2010HighfatDW,
  title={High-fat diet without excess calories induces metabolic disorders and enhances atherosclerosis in rabbits.},
  author={Ahmed Bilal Waqar and Tomonari Koike and Ying Di Yu and Tomohiro Inoue and Tadashi Aoki and Enqi Liu and Jianglin Fan},
  journal={Atherosclerosis},
  year={2010},
  volume={213 1},
  pages={148-55}
}
OBJECTIVE Excess intake of a high-fat diet (HFD) is associated with obesity and metabolic syndrome, which are major risk factors for cardiovascular disease. However, it is unclear whether consumption of an HFD at a normal calorific range would be detrimental to metabolism or affect the development of atherosclerosis. Here, we tested the hypothesis that consumption of a normal-calorie HFD would impair lipid metabolism, insulin sensitivity, and blood pressure. METHODS AND RESULTS Rabbits fed… CONTINUE READING
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