High-fat diet promotes and causes distal shift of experimental rat colonic cancer--beer and alcohol do not.

@article{Howarth1984HighfatDP,
  title={High-fat diet promotes and causes distal shift of experimental rat colonic cancer--beer and alcohol do not.},
  author={A E Howarth and E. A. Pihl},
  journal={Nutrition and cancer},
  year={1984},
  volume={6 4},
  pages={229-35}
}
Intestinal cancer was induced in inbred male D/A rats by 1,2-dimethylhydrazine, and the interrelationships between a high-fat (33.5% w/w) diet, beer and alcohol (4.8% v/v) ingestion, and tumor location and incidence were examined. The number of tumors per animal was significantly greater in both the small and large intestines of rats on the high-fat diet, as opposed to the standard diet. The 6-fold increase in incidence of colorectal cancer occurred almost exclusively in the distal half of the… CONTINUE READING