High-fat diet-induced ultradian leptin and insulin hypersecretion are absent in obesity-resistant rats.

Abstract

OBJECTIVE Sprague-Dawley rats fed a high-fat diet (HFD) are either obesity prone (OP) or obesity resistant (OR). We tested the hypothesis that differences in the ultradian rhythmic patterns of insulin and ghrelin in OP vs. OR rats promote obesity in OP rats. RESEARCH METHODS AND PROCEDURES Rats were fed regular chow or an HFD, and ultradian fluctuations… (More)

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