High-fat diet-induced reduction in nitric oxide-dependent arteriolar dilation in rats: role of xanthine oxidase-derived superoxide anion.

@article{Erdei2006HighfatDR,
  title={High-fat diet-induced reduction in nitric oxide-dependent arteriolar dilation in rats: role of xanthine oxidase-derived superoxide anion.},
  author={N{\'o}ra Erdei and Attila T{\'o}th and Enikő T. P{\'a}sztor and Zolt{\'a}n Papp and Istv{\'a}n {\'E}des and A. E. Koller and Zsolt Bagi},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={291 5},
  pages={H2107-15}
}
Obesity frequently leads to the development of hypertension. We hypothesized that high-fat diet (HFD)-induced obesity impairs the endothelium-dependent dilation of arterioles. Male Wistar rats were fed with normal (control) or HFD (60% of saturated fat, for 10 wk). In rats with HFD, body weight, mean arterial blood pressure, and serum insulin, cholesterol, and glucose were elevated. In isolated gracilis muscle arterioles (diameter: approximately 160 microm) of HFD, rat dilations to ACh (at 1… CONTINUE READING