High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats

Abstract

Leptin is an adipokine involved in body weight and food intake regulation whose promoter region presents CpG islands that could be subject to dynamic methylation. This methylation process could be affected by environmental (e.g. diet) or endogenous (e.g., adipocyte differentiation, inflammation, hypoxia) factors, and could influence adipocyte leptin gene… (More)
DOI: 10.1007/BF03165964

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