High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.

@article{Mitra2008HighFD,
  title={High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.},
  author={Mayurranjan S. Mitra and Shashikiran Donthamsetty and Brent A White and Harihara M. Mehendale},
  journal={Toxicology and applied pharmacology},
  year={2008},
  volume={231 3},
  pages={413-22}
}
Often, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity. This cardioprotection is accompanied by decreased cardiac oxidative stress and triglycerides and increased cardiac fatty-acid oxidation, ATP synthesis, and upregulated JAK/STAT3 pathway. In the current study, we investigated whether a… CONTINUE READING