High-fat diet consumption during pregnancy and the early post-natal period leads to decreased α cell plasticity in the nonhuman primate.

@article{Comstock2012HighfatDC,
  title={High-fat diet consumption during pregnancy and the early post-natal period leads to decreased α cell plasticity in the nonhuman primate.},
  author={Sarah M. Comstock and Lynley D. Pound and Jacalyn M Bishop and Diana L. Takahashi and Ashley M Kostrba and M Susan Smith and Kevin L. Grove},
  journal={Molecular metabolism},
  year={2012},
  volume={2 1},
  pages={10-22}
}
We investigated the impact of poor maternal nutrition and metabolic health on the development of islets of the nonhuman primate (NHP). Interestingly, fetal offspring of high fat diet (HFD) fed animals had normal total islet and β cell mass; however, there was a significant reduction in α cell mass, and decreased expression of transcription factors involved in α cell differentiation. In juvenile animals all offspring maintained on a HFD during the postweaning period demonstrated increases in… CONTINUE READING
14 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…